Synthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer
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Data
2014-05-01
Autores
Reis, Juliana Santana [UNESP]
Correa, Marcos Antonio [UNESP]
Chin, Chung Man [UNESP]
Santos, Jean Leandro dos [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier B.V.
Resumo
Chronic ultraviolet (UV) radiation exposure is a major cause of skin cancer. A novel series of hybrid derivatives (I-VIII) for use in sunscreen formulations were synthesized by molecular hybridization of t-resveratrol, avobenzone, and octyl methoxycinnamate, and were characterized. The antioxidant activity values for VIII were comparable than to those of t-resveratrol. Compounds I-III and VI demonstrated Sun Protector Factor superior to that of t-resveratrol. Compounds I and IV-VIII were identified as new, broad-spectrum UVA filters while II-III were UVB filters. In conclusion, novel hybrid derivatives with antioxidant effects have emerged as novel photoprotective agents for the prevention of skin cancer. (C) 2014 Elsevier Ltd. All rights reserved.
Descrição
Palavras-chave
Sunscreens, Photoprotection, Antioxidant, UV radiation, UV filters, t-Resveratrol, Avobenzone, Octyl methoxycinnamate, Molecular hybridization
Como citar
Bioorganic & Medicinal Chemistry. Oxford: Pergamon-elsevier Science Ltd, v. 22, n. 9, p. 2733-2738, 2014.