Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment
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Data
2019-09-02
Autores
Morise, B. T. [UNESP]
Chagas, A. L.D. [UNESP]
Barros, N. R. [UNESP]
Miranda, M. C.R. [UNESP]
Borges, F. A. [UNESP]
Gemeinder, J. L.P. [UNESP]
Silva, R. G. [UNESP]
Paulino, C. G. [UNESP]
Herculano, R. D. [UNESP]
Norberto, A. M.Q.
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Resumo
Sialorrhea is characterized by an increase in salivation. One of the adverse reactions of scopolamine is the decrease of salivary volume. Natural rubber latex can be used as a carrier matrix. This study developed and characterized a transdermal drug delivery system using natural rubber latex membranes carried with scopolamine butylbromide, using optical spectroscopy, Infrared spectroscopy, wettability, Scanning Electron Microscopy and hemolytic assays. The kinetic profile of scopolamine butylbromide showed that matrix released 96.49% of the drug and tests showed no hemolytic effects. Physico-chemical characterization and tensile tests showed that this system is a potential alternative for the treatment of sialorrhea.
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biomaterial, natural rubber latex, scopolamine, Sialorrhea, sustained release
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International Journal of Polymeric Materials and Polymeric Biomaterials, v. 68, n. 13, p. 788-795, 2019.