Publicação: OBTENCAO DE MESALAZINA (5-ASA) POR CARBOXILACAO DE P-AMINOFENOL
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The 5-aminosalicylic acid is usually prepared: 1. by the reduction of the azodye from diazotized aniline and salicylic acid and the posterior reduction of the formed compound; 2. for carboxylation with carbon dioxide under high pressure of p-aminophenol. Both do not present high yield, but the carboxylation process of p-aminophenol can easily be used and can reduce the obtainment process of 3 steps to only 2. Another advantage of this process is the fact that the product is produced without contaminants, because only one solid reagent (p-aminophenol) and the agent of carboxylation (CO2) is used.
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5-aminosalicylic acid, drug synthesis, salicylic derivatives, ulcerative colitis, 4 aminophenol, mesalazine, carboxylation, drug manufacture
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Português
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Revista de Ciencias Farmaceuticas, v. 16, p. 105-110.
