Byrsonima fagifolia Niedenzu Apolar Compounds with Antitubercular Activity
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2011-01-01
Autores
Higuchi, Célio Takashi [UNESP]
Sannomiya, M. [UNESP]
Pavan, Fernando Rogério [UNESP]
Leite, S. R. A. [UNESP]
Sato, D. N.
Franzblau, S. G.
Sacramento, Luis Vitor Silva do [UNESP]
Vilegas, Wagner [UNESP]
Leite, Clarice Queico Fujimura [UNESP]
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Hindawi Publishing Corporation
Resumo
Bioassay-guided fractionation of the chloroform extract of Byrsonima fagifolia leaves led to the isolation of active antitubercular compounds alkane dotriacontane (Minimal Inhibitory Concentration-MIC, 62.5 mu g mL(-1)), triterpenoids as bassic acid (MIC = 2.5 mu g mL(-1)), alpha-amyrin acetate (MIC = 62.5 mu g mL(-1)), a mixture of lupeol, alpha- and beta-amyrin (MIC = 31.5 mu g mL(-1)) and a mixture of lupeol, and acetates of alpha- and beta-amyrin (MIC = 31.5 mu g mL(-1)). The antimycobacterial activity was determined by the Microplate Alamar Blue Assay (MABA) and the structures of promising compounds were determined by spectroscopic analysis. This investigation constitutes the first report of a chemical and antitubercular study of apolar compounds from B. fagifolia Niedenzu (IK).
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Evidence-based Complementary and Alternative Medicine. New York: Hindawi Publishing Corporation, p. 5, 2011.