Study of liposomes stability containing soy phosphatidyleholine and hydrogenated soy phosphatydylcholine adding or not cholesterol by turbidity method
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Data
2007-01-01
Autores
Chorilli, Marlus [UNESP]
Rimerio, Thereana Cristina
Oliveira, Anselmo Gomes de [UNESP]
Scarpa, Maria Virginia
Título da Revista
ISSN da Revista
Título de Volume
Editor
Colegio de Farmaceuticos de La Provincia de Buenos Aires
Resumo
Study of Liposomes Stability Containing Soy Phosphatidyleholine and Hydrogenated Soy Phosphatydylcholine Adding or Not Cholesterol by Turbidity Method. Liposomes are structures composed by phospholipids as soy phosphatidylcholine (PC) and hydrogenated soy phosphatydylcholine (PCH). Among the methods used to prove liposomes stability, turbidity method is widely used. The objective of this work was to study the liposomes stability containing PC or PCH with and without cholesterol (CHOL) by turbidity method. Liposomes were stored a 30 degrees C during 90 days and periodically absorbance readings at 410 nm were made to verify possible turbidity alterations. Increases in the turbidity with time occurred for PC liposomes. In the presence of CHOL higher turbidity was obtained probably reflecting the increase in the size of liposomes. For PCH liposomes the presence of CHOL did not affect the turbidity suggesting higher physical stability of the structures.
Descrição
Palavras-chave
liposomes, hydrogenated soy phosphatidylcholine, soy phosphatidylcholine, turbidity
Como citar
Latin American Journal of Pharmacy. La Plata: Colegio de Farmaceuticos de La Provincia de Buenos Aires, v. 26, n. 1, p. 31-37, 2007.