A Review of Analytical Techniques for Determination of Glimepiride: Present and Perspectives
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Data
2010-10-01
Autores
Bonfilio, Rudy [UNESP]
de Araujo, Magali Benjamim
Salgado, Hérida Regina Nunes [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Lippincott Williams & Wilkins
Resumo
Glimepiride is an oral antidiabetic drug in the sulfonylurea class, which is widely used in treatment of Type 2 diabetes and it is currently available in more than 60 countries worldwide. As a result of the importance of this oral hypoglycemic agent in the treatment of noninsulin-dependent diabetes mellitus, this work aims to compile the published analytical methods reported so far in the literature for determination of glimepiride in biologic samples and pharmaceutical formulations. Techniques like high-performance liquid chromatography with ultraviolet, array-diode, mass spectroscopy, evaporative light scattering and charged aerosol detections, liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry, liquid chromatography-electrospray ionization-tandem mass spectrometry, semimicrobore high-performance liquid chromatography with column-switching, micellar electrokinetic chromatography, high-performance thin layer chromatography, polarography, and spectrophotometry have been used for analysis, from which it can be seen that high-performance liquid chromatography methods have been used most extensively.
Descrição
Palavras-chave
glimepiride, type 2 diabetes, analytical methods, biologic samples, pharmaceuticals
Como citar
Therapeutic Drug Monitoring. Philadelphia: Lippincott Williams & Wilkins, v. 32, n. 5, p. 550-559, 2010.