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dc.contributor.authorSilva, Arnobio A. -Junior [UNESP]
dc.contributor.authorScarpa, Maria Virginia [UNESP]
dc.contributor.authorPestana, Kelly Chrystina [UNESP]
dc.contributor.authorMercuri, Lucildes Pita
dc.contributor.authorde Matos, Jivaldo Rosario
dc.contributor.authorOliveira, Anselmo Gomes de [UNESP]
dc.identifier.citationThermochimica Acta. Amsterdam: Elsevier B.V., v. 467, n. 1-2, p. 91-98, 2008.
dc.description.abstractThermal analysis has been extensively used to obtain information about drug-polymer interactions and to perform pre-formulation studies of pharmaceutical dosage forms. In this work, biodegradable microparticles of poly(D,L-lactide-co-glycolide) (PLGA) containing ciprofloxacin hydrochloride (CP) in various drug:polymer ratios were obtained by spray drying. The main purpose of this study was to investigate the effect of the spray drying process on the drug-polymer interactions and on the stability of microparticles using differential scanning calorimetry (DSC), thermogravimetry (TG) and derivative thermogravimetry (DTG) and infrared spectroscopy (IR). The results showed that the high levels of encapsulation efficiency were dependant on drug:polymer ratio. DSC and TG/DTG analyses showed that for physical mixtures of the microparticles components the thermal profiles were different from those signals obtained with the pure substances. Thermal analysis data disclosed that physical interaction between CP and PLGA in high temperatures had occurred. The DSC and TG profiles for drug-loaded microparticles were very similar to the physical mixtures of components and it was possible to characterize the thermal properties of microparticles according to drug content. These data indicated that the spray dryer technique does not affect the physicochemical properties of the microparticles. In addition, the results are in agreement with IR data analysis demonstrating that no significant chemical interaction occurs between CP and PLGA in both physical mixtures and microparticles. In conclusion, we have found that the spray drying procedure used in this work can be a secure methodology to produce CP-loaded microparticles. (C) 2007 Elsevier B.V. All rights reserved.en
dc.publisherElsevier B.V.
dc.relation.ispartofThermochimica Acta
dc.sourceWeb of Science
dc.subjectciprofloxacin hydrochlorideen
dc.subjectspray dryingen
dc.subjectthermal analysisen
dc.titleThermal analysis of biodegradable microparticles containing ciprofloxacin hydrochloride obtained by spray drying techniqueen
dcterms.rightsHolderElsevier B.V.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Cruzeiro Sul
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Ciencias Farmaceut, Program Pos Grad Ciencias Farmaceut, Araraquara, SP, Brazil
dc.description.affiliationUniv Cruzeiro Sul, Ctr Ciencias Exatas & Tecnol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Quim, Dept Quim Fundamental, BR-05508 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Ciencias Farmaceut, Program Pos Grad Ciencias Farmaceut, Araraquara, SP, Brazil
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
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