Chá mate (Ilex paraguariensis) melhora a defesa antioxidante e diminui o dano oxidativo em fêmeas Wistar senis
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Data
2013-08-05
Autores
Pereira, Ariana Aparecida Ferreira [UNESP]
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Universidade Estadual Paulista (Unesp)
Resumo
O envelhecimento em fêmeas é caracterizado por declínio progressivo nas funções bioquímicas e fisiológicas de vários tecidos e órgãos, que resulta em menor produção de estrógeno, diminuição da defesa antioxidante e aumento do estresse oxidativo. Ervas com poder antioxidante que possam minimizar os efeitos do estresse oxidativo na senilidade vem sendo estudadas e o Ilex paraguariensis (chá mate), consumido em alguns países da América do Sul na forma de chá, apresenta elevada capacidade antioxidante in vivo, além de aumentar a expressão de enzimas antioxidantes. Este trabalho analisou o efeito da administração de chá mate por 8 semanas, na defesa antioxidante e dano oxidativo de ratas jovens e senis. Fêmeas Wistar de 4 e 17 meses de idade foram distribuídas nos grupos: Senis (S), Senis tratadas com chá mate (SCM), Jovens (J) e Jovens tratadas com chá mate (JCM). Os grupos SCM e JCM receberam diariamente chá mate na dose de 20 mg/kg de massa corpórea, por oito semanas. Foram avaliadas a capacidade antioxidante no plasma, as substâncias reativas ao ácido tiobarbitúrico (TBARS) e a atividade das enzimas antioxidantes, superóxido dismutase, catalase e glutationa peroxidase no hemolisado e homogenato do fígado. O chá mate aumentou a capacidade antioxidante no plasma, diminuiu TBARS e elevou a atividade das enzimas antioxidantes no hemolisado e homogenato do fígado, porém as respostas ao tratamento foram influenciadas pela idade.
Aging process in females is characterized by a progressive decline in biochemical and physiological functions of various tissues and organs, resulting in decreased production of estrogen, decreased antioxidant defense and increased oxidative stress. Herbs with antioxidant properties that can minimize the effects of oxidative stress in aging have been studied and Ilex paraguariensis (mate tea), consumed in some countries of South America in the form of tea has high antioxidant capacity in vivo, in addition to increasing the expression of antioxidant enzymes. This study examined the effect of administration of mate tea for 8 weeks in antioxidant defense and oxidative damage in young and senile rats. Female rats (4 and 17 months of age) were allocated into groups: Senile (S), Senile treated with mate tea (SCM), Young (J) and Young treated with mate tea (JCM). SCM and JCM received daily mate tea (20 mg / kg body mass) for eight weeks. We evaluated the antioxidant capacity of plasma (FRAP), the thiobarbituric acid reactive substances (TBARS) and antioxidant enzymes, superoxide dismutase, catalase and glutathione peroxidase in liver homogenate and hemolysate. Mate tea increased the plasma FRAP, decreased TBARS and increased the antioxidant enzyme activity, both in hemolysate and liver homogenate, but responses to treatment were influenced by age.
Aging process in females is characterized by a progressive decline in biochemical and physiological functions of various tissues and organs, resulting in decreased production of estrogen, decreased antioxidant defense and increased oxidative stress. Herbs with antioxidant properties that can minimize the effects of oxidative stress in aging have been studied and Ilex paraguariensis (mate tea), consumed in some countries of South America in the form of tea has high antioxidant capacity in vivo, in addition to increasing the expression of antioxidant enzymes. This study examined the effect of administration of mate tea for 8 weeks in antioxidant defense and oxidative damage in young and senile rats. Female rats (4 and 17 months of age) were allocated into groups: Senile (S), Senile treated with mate tea (SCM), Young (J) and Young treated with mate tea (JCM). SCM and JCM received daily mate tea (20 mg / kg body mass) for eight weeks. We evaluated the antioxidant capacity of plasma (FRAP), the thiobarbituric acid reactive substances (TBARS) and antioxidant enzymes, superoxide dismutase, catalase and glutathione peroxidase in liver homogenate and hemolysate. Mate tea increased the plasma FRAP, decreased TBARS and increased the antioxidant enzyme activity, both in hemolysate and liver homogenate, but responses to treatment were influenced by age.
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Palavras-chave
Erva-mate, Ilex paraguariensis, Antioxidantes, Envelhecimento, Stress oxidativo, Rato
Como citar
PEREIRA, Ariana Aparecida Ferreira. Chá mate (Ilex paraguariensis) melhora a defesa antioxidante e diminui o dano oxidativo em fêmeas Wistar senis. 2013. 102 f. Dissertação (mestrado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Odontologia de Araçatuba, 2013.