Prostaglandin E-2 and the Suppression of Phagocyte Innate Immune Responses in Different Organs
Carregando...
Arquivos
Data
2012-01-01
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Hindawi Publishing Corporation
Tipo
Artigo
Direito de acesso
Acesso aberto
Resumo
The local and systemic production of prostaglandin E-2 (PGE(2)) and its actions in phagocytes lead to immunosuppressive conditions. PGE2 is produced at high levels during inflammation, and its suppressive effects are caused by the ligation of the E prostanoid receptors EP2 and EP4, which results in the production of cyclic AMP. However, PGE(2) also exhibits immunostimulatory properties due to binding to EP3, which results in decreased cAMP levels. The various guanine nucleotide-binding proteins (G proteins) that are coupled to the different EP receptors account for the pleiotropic roles of PGE(2) in different disease states. Here, we discuss the production of PGE(2) and the actions of this prostanoid in phagocytes from different tissues, the relative contribution of PGE(2) to the modulation of innate immune responses, and the novel therapeutic opportunities that can be used to control inflammatory responses.
Descrição
Palavras-chave
Idioma
Inglês
Como citar
Mediators of Inflammation. New York: Hindawi Publishing Corporation, p. 13, 2012.