Chemical Composition and Trypanocidal Activity of the Essential Oils from Hedychium coronarium J. Koenig (Zingiberaceae)

Rodrigues, Danilo Fernando [UNESP]; Arenas Velásquez, Angela María [UNESP]; Cavaleiro, Carlos; Salgueiro, Lígia; Martins, Gilmárcio Zimmermann [UNESP]; Magalhães, Nathália Oliveira [UNESP]; Martins, Maria Bernadete GonÇalves [UNESP]; Cicarelli, Regina Maria Barretto [UNESP]; Moreira, Raquel Regina Duarte [UNESP]

Chemical Composition and Trypanocidal Activity of the Essential Oils from Hedychium coronarium J. Koenig (Zingiberaceae)

Arquivos

ISSN2090-8725-2013-2013-01-06.pdf (1.34 MB)

Data

2013

Autores

Rodrigues, Danilo Fernando

Arenas Velásquez, Angela María

Cavaleiro, Carlos

Salgueiro, Lígia

Martins, Gilmárcio Zimmermann

Magalhães, Nathália Oliveira

Martins, Maria Bernadete GonÇalves

Cicarelli, Regina Maria Barretto

Moreira, Raquel Regina Duarte

Tipo

Artigo

Direito de acesso

Acesso aberto

Resumo

The composition of the essential oils (EO) from leaves and rhizomes of Hedychium coronarium was analyzed both by gas chromatography and gas chromatography-mass spectroscopy. Thirty and thirty-nine compounds were identified, respectively, in the oils from leaves and rhizomes, representing 88% and 86.1% of the whole compositions. Caryophyllene oxide is the major component in rhizomes while 1,8-cineole predominates in leaves oil. Essential oils and major components were tested for trypanocidal activity using procyclic forms of Trypanosoma brucei (427 and 29-13 strains). The cytotoxicity index (CI50), using the MTT colorimetric method, showed that essential oils and 1,8-cineole were inactive (>100 μg·mL−1. Nevertheless, caryophyllene oxide revealed a remarkable activity against both T. brucei strains (CI50 = 65.77 μg·mL−1 and 24.53 μg·mL−1, resp.), and the synergism between caryophyllene oxide plus pentamidine (1 : 1, v/v) highly increased the trypanocidal activity (<1.0 μg·mL−1).