Chemical Composition and Trypanocidal Activity of the Essential Oils from Hedychium coronarium J. Koenig (Zingiberaceae)

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dc.contributor.authorRodrigues, Danilo Fernando [UNESP]
dc.contributor.authorArenas Velásquez, Angela María [UNESP]
dc.contributor.authorCavaleiro, Carlos
dc.contributor.authorSalgueiro, Lígia
dc.contributor.authorMartins, Gilmárcio Zimmermann [UNESP]
dc.contributor.authorMagalhães, Nathália Oliveira [UNESP]
dc.contributor.authorMartins, Maria Bernadete GonÇalves [UNESP]
dc.contributor.authorCicarelli, Regina Maria Barretto [UNESP]
dc.contributor.authorMoreira, Raquel Regina Duarte [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de Coimbra (UC)
dc.date.accessioned2015-05-15T13:30:33Z
dc.date.available2015-05-15T13:30:33Z
dc.date.issued2013
dc.description.abstractThe composition of the essential oils (EO) from leaves and rhizomes of Hedychium coronarium was analyzed both by gas chromatography and gas chromatography-mass spectroscopy. Thirty and thirty-nine compounds were identified, respectively, in the oils from leaves and rhizomes, representing 88% and 86.1% of the whole compositions. Caryophyllene oxide is the major component in rhizomes while 1,8-cineole predominates in leaves oil. Essential oils and major components were tested for trypanocidal activity using procyclic forms of Trypanosoma brucei (427 and 29-13 strains). The cytotoxicity index (CI50), using the MTT colorimetric method, showed that essential oils and 1,8-cineole were inactive (>100 μg·mL−1. Nevertheless, caryophyllene oxide revealed a remarkable activity against both T. brucei strains (CI50 = 65.77 μg·mL−1 and 24.53 μg·mL−1, resp.), and the synergism between caryophyllene oxide plus pentamidine (1 : 1, v/v) highly increased the trypanocidal activity (<1.0 μg·mL−1).en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rodovia Araraquara-Jau, km 01, Campus, CEP 14801902, SP, Brasil
dc.description.affiliationUnespDepartment of Biological Sciences, School of Pharmaceutical Sciences of Araraquara, UNESP, São Paulo State University, 14801-902 Araraquara, SP, Brazil
dc.description.affiliationUnespInstitute of Chemistry, UNESP, São Paulo State University, 14800-900 Araraquara, SP, Brazil
dc.description.affiliationUnespDepartment of Natural Active Principles and Toxicology, School of Pharmaceutical Sciences of Araraquara, UNESP, São Paulo State University, 14801-902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, São Paulo State University, Coast Campus, 11330-900 São Vicente, SP, Brazil
dc.description.sponsorshipFundação para a Ciência e a Tecnologia (FCT)
dc.description.sponsorshipFundação para o Desenvolvimento da Unesp (FUNDUNESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdPOCI 2010/FEDER
dc.format.extent1-6
dc.identifierhttp://www.hindawi.com/journals/isrn/2013/639275/
dc.identifier.citationISRN Infectious Diseases, v. 2013, p. 1-6, 2013.
dc.identifier.doi10.5402/2013/639275
dc.identifier.fileISSN2090-8725-2013-2013-01-06.pdf
dc.identifier.issn2090-8725
dc.identifier.lattes9703848266137282
dc.identifier.lattes7710344461864924
dc.identifier.orcid0000-0002-4253-0320
dc.identifier.urihttp://hdl.handle.net/11449/123640
dc.language.isoeng
dc.relation.ispartofISRN Infectious Diseases
dc.rights.accessRightsAcesso aberto
dc.sourceCurrículo Lattes
dc.subjectchemical composition of essential oilsen
dc.subjecttrypanocidal activityen
dc.subjectTrypanosoma bruceien
dc.titleChemical Composition and Trypanocidal Activity of the Essential Oils from Hedychium coronarium J. Koenig (Zingiberaceae)en
dc.typeArtigo
unesp.author.lattes9703848266137282
unesp.author.lattes7710344461864924[9]
unesp.author.orcid0000-0002-4253-0320[9]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentCiências Biológicas - FCFpt
unesp.departmentPrincípios Ativos Naturais e Toxicologia - FCFpt

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