Chemical Composition and Trypanocidal Activity of the Essential Oils from Hedychium coronarium J. Koenig (Zingiberaceae)
dc.contributor.author | Rodrigues, Danilo Fernando [UNESP] | |
dc.contributor.author | Arenas Velásquez, Angela María [UNESP] | |
dc.contributor.author | Cavaleiro, Carlos | |
dc.contributor.author | Salgueiro, Lígia | |
dc.contributor.author | Martins, Gilmárcio Zimmermann [UNESP] | |
dc.contributor.author | Magalhães, Nathália Oliveira [UNESP] | |
dc.contributor.author | Martins, Maria Bernadete GonÇalves [UNESP] | |
dc.contributor.author | Cicarelli, Regina Maria Barretto [UNESP] | |
dc.contributor.author | Moreira, Raquel Regina Duarte [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade de Coimbra (UC) | |
dc.date.accessioned | 2015-05-15T13:30:33Z | |
dc.date.available | 2015-05-15T13:30:33Z | |
dc.date.issued | 2013 | |
dc.description.abstract | The composition of the essential oils (EO) from leaves and rhizomes of Hedychium coronarium was analyzed both by gas chromatography and gas chromatography-mass spectroscopy. Thirty and thirty-nine compounds were identified, respectively, in the oils from leaves and rhizomes, representing 88% and 86.1% of the whole compositions. Caryophyllene oxide is the major component in rhizomes while 1,8-cineole predominates in leaves oil. Essential oils and major components were tested for trypanocidal activity using procyclic forms of Trypanosoma brucei (427 and 29-13 strains). The cytotoxicity index (CI50), using the MTT colorimetric method, showed that essential oils and 1,8-cineole were inactive (>100 μg·mL−1. Nevertheless, caryophyllene oxide revealed a remarkable activity against both T. brucei strains (CI50 = 65.77 μg·mL−1 and 24.53 μg·mL−1, resp.), and the synergism between caryophyllene oxide plus pentamidine (1 : 1, v/v) highly increased the trypanocidal activity (<1.0 μg·mL−1). | en |
dc.description.affiliation | Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rodovia Araraquara-Jau, km 01, Campus, CEP 14801902, SP, Brasil | |
dc.description.affiliationUnesp | Department of Biological Sciences, School of Pharmaceutical Sciences of Araraquara, UNESP, São Paulo State University, 14801-902 Araraquara, SP, Brazil | |
dc.description.affiliationUnesp | Institute of Chemistry, UNESP, São Paulo State University, 14800-900 Araraquara, SP, Brazil | |
dc.description.affiliationUnesp | Department of Natural Active Principles and Toxicology, School of Pharmaceutical Sciences of Araraquara, UNESP, São Paulo State University, 14801-902 Araraquara, SP, Brazil | |
dc.description.affiliationUnesp | UNESP, São Paulo State University, Coast Campus, 11330-900 São Vicente, SP, Brazil | |
dc.description.sponsorship | Fundação para a Ciência e a Tecnologia (FCT) | |
dc.description.sponsorship | Fundação para o Desenvolvimento da Unesp (FUNDUNESP) | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorshipId | POCI 2010/FEDER | |
dc.format.extent | 1-6 | |
dc.identifier | http://www.hindawi.com/journals/isrn/2013/639275/ | |
dc.identifier.citation | ISRN Infectious Diseases, v. 2013, p. 1-6, 2013. | |
dc.identifier.doi | 10.5402/2013/639275 | |
dc.identifier.file | ISSN2090-8725-2013-2013-01-06.pdf | |
dc.identifier.issn | 2090-8725 | |
dc.identifier.lattes | 9703848266137282 | |
dc.identifier.lattes | 7710344461864924 | |
dc.identifier.orcid | 0000-0002-4253-0320 | |
dc.identifier.uri | http://hdl.handle.net/11449/123640 | |
dc.language.iso | eng | |
dc.relation.ispartof | ISRN Infectious Diseases | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Currículo Lattes | |
dc.subject | chemical composition of essential oils | en |
dc.subject | trypanocidal activity | en |
dc.subject | Trypanosoma brucei | en |
dc.title | Chemical Composition and Trypanocidal Activity of the Essential Oils from Hedychium coronarium J. Koenig (Zingiberaceae) | en |
dc.type | Artigo | |
unesp.author.lattes | 9703848266137282 | |
unesp.author.lattes | 7710344461864924[9] | |
unesp.author.orcid | 0000-0002-4253-0320[9] | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
unesp.department | Ciências Biológicas - FCF | pt |
unesp.department | Princípios Ativos Naturais e Toxicologia - FCF | pt |
Arquivos
Pacote Original
1 - 1 de 1
Carregando...
- Nome:
- ISSN2090-8725-2013-2013-01-06.pdf
- Tamanho:
- 1.34 MB
- Formato:
- Adobe Portable Document Format