Effects of Formulations Containing Dimethylaminoethanol (DMAE) Acetoamidobenzoate and Pidolate on the Skin

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Guimaraes, Gustavo N.
Chorilli, Marlus [UNESP]
Leonardi, Gislaine R.
Prestes, Paula S.
Garcia, Gislene
Pires-De-Campos, Maria S. M.
Polacow, Maria L. O.

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Colegio Farmaceuticos Provincia de Buenos Aires


The aim of this study was to analyze the effects of formulations containing DMAE pidolate and DMAE acetoamidobenzoate on the skin. Four areas of five swines were submitted to following treatments during 15 days: C (Control), S (Silicone = 80 % DC*LC Blend (R)), F1 (DMAE acetoamidobenzoate), F2 (DMAE pidolate). Measures of the thickness of epidermis and stratum corneum, and the density population of fibroblasts and leukocytes in papillary dermis were obtained. We also assessed possible variations in birefringence of dermis collagen bundles. Means of the data was compared using ANOVA followed by the Tukey test. The F1 and F2 groups showed a thicker epidermis than the control group (p < 0.01), but did not demonstrate a significant difference in the number of fibroblasts and leukocytes, as well as in the birefringent areas of collagen bundles, in comparison with the control groups. The DMAE-supplemented formulations enhanced viable epidermis thickness, but did not modify structures related with mechanical properties of the skin.



Dimethylaminoethanol, Histopatology, Skin

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Latin American Journal of Pharmacy. La Plata: Colegio Farmaceuticos Provincia de Buenos Aires, v. 30, n. 4, p. 641-646, 2011.