Evaluation of cytoprotective effects of compounds isolated fromCopaifera langsdorffiiDesf. against induced cytotoxicity by exposure to methylmercury and lead

Nenhuma Miniatura disponível

Data

2020-09-01

Orientador

Coorientador

Pós-graduação

Curso de graduação

Título da Revista

ISSN da Revista

Título de Volume

Editor

Taylor & Francis Ltd

Tipo

Artigo

Direito de acesso

Resumo

Copaifera langsdorffiiL. is one of the most known medicinal species in Brazil. Its leaves are rich in phenolic compounds with potential biological activities as an antioxidant and chelating agent. This paper reports the isolation of four compounds from the hydroalcoholic extract of the leaves ofC. langsdorffiiand the investigation of their possible cytoprotective effects against heavy metal poisoning. Quercitrin (1), afzelin (2), 3,5-di-O-(3-O-methyl galloyl) quinic acid (3) and 4,5-di-O-(3-O-methyl galloyl) quinic acid (4), were associated with toxic doses of methylmercury and lead and evaluated by Alamar blue cell viability assays in HepG2 and PC12. The compounds displayed significant cytoprotective effect for the HepG2 cell line against both metals. Compounds 1-4 did not protect PC12 cells against methylmercury induced-cytotoxicity, but at lower concentrations, they protected against lead induced-cytotoxicity. The evaluated compounds showed a promising cytoprotection effect against exposure to heavy metals and should be further investigated as protective agents.

Descrição

Idioma

Inglês

Como citar

Natural Product Research. Abingdon: Taylor & Francis Ltd, v. 34, n. 17, p. 2528-2532, 2020.

Itens relacionados

Financiadores