Publicação: Development and validation of an UV spectrophotometric method for determination of gatifloxacin in tablets
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Data
2005-04-01
Orientador
Coorientador
Pós-graduação
Curso de graduação
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Tipo
Artigo
Direito de acesso
Acesso aberto
Resumo
A simple, sensitive and accurate spectrophotometric method was developed for the assay of gatifloxacin in raw material and tablets. Validation of the method yielded good results concerning range, linearity, precision and accuracy. The absorbance was measured at 287 nm for gatifloxacin tablet solutions. The linearity range was found to be 4.0-14.0 μg/mL for gatifloxacin. It was also found that the excipients in the commercial tablets did not interfere with the method.
Descrição
Palavras-chave
excipient, gatifloxacin, quinoline derived antiinfective agent, accuracy, analytic method, aqueous solution, calibration, correlation coefficient, drug determination, linear regression analysis, reproducibility, statistical analysis, tablet formulation, ultraviolet spectrophotometry, validation process, Anti-Infective Agents, Calibration, Fluoroquinolones, Reference Standards, Reproducibility of Results, Spectrophotometry, Ultraviolet, Tablets
Idioma
Inglês
Como citar
Pharmazie, v. 60, n. 4, p. 263-264, 2005.
